Update pharmacokinetic parameters/calculations, add advanced settings, add disclaimer/citations, many improvements

src/utils/calculations.ts

@@ -28,7 +28,12 @@ export const calculateCombinedProfile = (
   const timeStepHours = 0.25;
   const totalDays = days.length;
   const totalHours = totalDays * 24;
-  const daysToSimulate = Math.min(parseInt(steadyStateConfig.daysOnMedication, 10) || 0, 5);
+
+  // Use steadyStateDays from advanced settings (allows 0 for "first day" simulation)
+  const daysToSimulate = Math.min(
+    parseInt(pkParams.advanced.steadyStateDays, 10) || 0,
+    7 // cap at 7 days for performance
+  );
 
   // Convert days to processed doses with absolute time
   const allDoses: ProcessedDose[] = [];
@@ -36,7 +41,7 @@ export const calculateCombinedProfile = (
   // Add steady-state doses (days before simulation period)
   // Use template day (first day) for steady state
   const templateDay = days[0];
-  if (templateDay) {
+  if (templateDay && daysToSimulate > 0) {
     for (let steadyDay = -daysToSimulate; steadyDay < 0; steadyDay++) {
       const dayOffsetMinutes = steadyDay * 24 * 60;
       templateDay.doses.forEach(dose => {