Fix various issues with pharmacokinetics, improved parameters, distinction between adult/child

src/locales/en.ts

@@ -24,6 +24,8 @@ export const en = {
   afternoon: "Afternoon",
   evening: "Evening",
   night: "Night",
+  doseWithFood: "Taken with food (delays absorption ~1h)",
+  doseFasted: "Taken fasted (normal absorption)",
 
   // Deviations
   deviationsFromPlan: "Deviations from Plan",
@@ -70,6 +72,12 @@ export const en = {
   pharmacokineticsSettings: "Pharmacokinetics Settings",
   advancedSettings: "Advanced Settings",
   advancedSettingsWarning: "⚠️ These parameters affect simulation accuracy and may deviate from population averages. Adjust only if you have specific clinical data or research references.",
+  standardVolumeOfDistribution: "Volume of Distribution (Vd)",
+  standardVdTooltip: "Defines how drug disperses in body. Adult: 377L (Roberts 2015), Child: ~150-200L. Affects all concentration calculations. Change only for pediatric or specialized simulations. Default: {{standardVdValue}}L ({{standardVdPreset}}).",
+  standardVdPresetAdult: "Adult (377L)",
+  standardVdPresetChild: "Child (175L)",
+  standardVdPresetCustom: "Custom",
+  customVdValue: "Custom Vd (L)",
   xAxisTimeFormat: "Time Format",
   xAxisFormatContinuous: "Continuous",
   xAxisFormatContinuousDesc: "Endless sequence (0h, 6h, 12h...)",
@@ -94,7 +102,7 @@ export const en = {
   yAxisRangeAutoButtonTitle: "Determine range automatically based on data range",
   auto: "Auto",
   therapeuticRange: "Therapeutic Range",
-  therapeuticRangeTooltip: "Reference concentrations for medication efficacy. Typical adult range: 5-25 ng/mL. Individual therapeutic windows vary significantly. Default: {{therapeuticRangeMin}}-{{therapeuticRangeMax}} ng/mL. Consult your physician.",
+  therapeuticRangeTooltip: "Personalized concentration targets based on YOUR individual response. Set these after observing which levels provide symptom control vs. side effects. Reference ranges (highly variable): Adults ~10-80 ng/mL, Children ~20-120 ng/mL (due to lower body weight/Vd). Leave empty if unsure. Consult your physician.",
   dAmphetamineParameters: "d-Amphetamine Parameters",
   halfLife: "Elimination Half-life",
   halfLifeTooltip: "Time for body to clear half the d-amphetamine from blood. Affected by urine pH: acidic (<6) → 7-9h, neutral (6-7.5) → 10-12h, alkaline (>7.5) → 13-15h. See [therapeutic reference ranges](https://www.thieme-connect.com/products/ejournals/pdf/10.1055/a-2689-4911.pdf). Default: {{damphHalfLife}}h.",
@@ -113,9 +121,10 @@ export const en = {
   bodyWeightUnit: "kg",
 
   foodEffectEnabled: "Taken With Meal",
+  foodEffectDelay: "Food Effect Delay",
   foodEffectTooltip: "High-fat meals delay absorption without changing total exposure. Slows onset of effects (~1h delay). When disabled, assumes fasted state.",
   tmaxDelay: "Absorption Delay",
-  tmaxDelayTooltip: "How much the meal delays absorption (Tmax shift). See [food effect study](https://pmc.ncbi.nlm.nih.gov/articles/PMC4823324/) by Ermer et al. Typical: 1.0h for high-fat meal. Default: {{tmaxDelay}}h.",
+  tmaxDelayTooltip: "Time delay when dose is taken with high-fat meal. Applied using per-dose food toggles (🍴 icon) in schedule. Research shows ~1h delay without peak reduction. See [study](https://pmc.ncbi.nlm.nih.gov/articles/PMC4823324/). Default: {{tmaxDelay}}h.",
   tmaxDelayUnit: "h",
 
   urinePHTendency: "Urine pH Effects",
@@ -131,6 +140,21 @@ export const en = {
   steadyStateDays: "Medication History",
   steadyStateDaysTooltip: "Number of prior days on stable medication dose to simulate accumulation/steady-state. Set 0 for \"first day from scratch.\" Default: {{steadyStateDays}} days. Max: 7.",
 
+  // Age-specific pharmacokinetics
+  ageGroup: "Age Group",
+  ageGroupTooltip: "Pediatric subjects (6-12y) exhibit faster d-amphetamine elimination (t½ ~9h) compared to adults (~11h) due to higher weight-normalized metabolic rate. See [research document](https://git.11001001.org/cbaoth/med-plan-assistant/src/branch/main/docs/2026-01-17_AI-Reseach_SimulatingLDXandD-AmphetaminePlasmaLevels.md#52-pediatric-vs-adult-modeling) Section 5.2. Select 'custom' to use your manually configured half-life. Default: adult.",
+  ageGroupAdult: "Adult (t½ 11h)",
+  ageGroupChild: "Child 6-12y (t½ 9h)",
+  ageGroupCustom: "Custom (use manual t½)",
+
+  // Renal function effects
+  renalFunction: "Renal Impairment",
+  renalFunctionTooltip: "Severe renal impairment extends d-amphetamine half-life by ~50% (from 11h to 16.5h). FDA label recommends dose caps: 50mg for severe impairment, 30mg for ESRD. See [FDA Label Section 8.6](https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021977s049lbl.pdf) and [research document](https://git.11001001.org/cbaoth/med-plan-assistant/src/branch/main/docs/2026-01-17_AI-Reseach_SimulatingLDXandD-AmphetaminePlasmaLevels.md#82-renal-function) Section 8.2. Default: disabled.",
+  renalFunctionSeverity: "Impairment Severity",
+  renalFunctionNormal: "Normal (no adjustment)",
+  renalFunctionMild: "Mild (no adjustment)",
+  renalFunctionSevere: "Severe (t½ +50%)",
+
   resetAllSettings: "Reset All Settings",
   resetDiagramSettings: "Reset Diagram Settings",
   resetPharmacokineticSettings: "Reset Pharmacokinetic Settings",