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Update combined static Vd and weight-based settings

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This commit is contained in:
Andreas Weyer
2026-02-07 10:12:06 +00:00
parent b7a585a223
commit 199872d742
7 changed files with 73 additions and 77 deletions
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src/locales/en.ts
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@@ -78,11 +78,13 @@ export const en = {
advancedSettings: "Advanced Settings",
advancedSettingsWarning: "⚠️ These parameters affect simulation accuracy and may deviate from population averages. Adjust only if you have specific clinical data or research references.",
standardVolumeOfDistribution: "Volume of Distribution (Vd)",
standardVdTooltip: "Defines how drug disperses in body. Adult: 377L (Roberts 2015), Child: ~150-200L. Affects all concentration calculations. Change only for pediatric or specialized simulations. Default: {{standardVdValue}}L ({{standardVdPreset}}).",
standardVdTooltip: "Defines how drug disperses in body. Adult: 377L (Roberts 2015), Child: ~150-200L. Weight-based scaling: ~5.4 L/kg (intended for adults >18 years based on [population PK analysis](https://pmc.ncbi.nlm.nih.gov/articles/PMC5572767/)). Affects all concentration calculations. Change only for pediatric or specialized simulations. Default: {{standardVdValue}}L ({{standardVdPreset}}).",
standardVdPresetAdult: "Adult (377L)",
standardVdPresetChild: "Child (175L)",
standardVdPresetCustom: "Custom",
standardVdPresetWeightBased: "Weight-Based (~5.4 L/kg)",
customVdValue: "Custom Vd (L)",
weightBasedVdInfo: "Weight-based Vd adjusts plasma concentrations based on body weight (~5.4 L/kg). Lighter persons → higher peaks, heavier → lower peaks. This option is intended for adults (>18 years) based on the population PK study. For pediatric patients, use the 'Child' preset.",
xAxisTimeFormat: "Time Format",
xAxisFormatContinuous: "Continuous",
xAxisFormatContinuousDesc: "Endless sequence (0h, 6h, 12h...)",